Abstract
1 Department of Microbiology, Maharashtra Institute of Medical Sciences and Research, Medical College and Hospital, Latur 413 531, Maharashtra, India
2 Department of Surgery, Maharashtra Institute of Medical Sciences and Research, Medical College and Hospital, Latur 413 531, Maharashtra, India
3 Department of Microbiology, Medical Microbiology Research Laboratory, Napur University, Nagpur, India
4 Department of Pathology, BLDE's B. M. Patil Medical College, Bijapur, India
5 Department of Pharmacology, Maharashtra Institute of Medical Sciences and Research Medical College, Latur, India
Correspondence
B. S. Nagoba
(dr_bsnagoba{at}yahoo.com
or
bsnagoba{at}indiatimes.com )
Citric acid treatment of chronic infected wounds offers excellent results. It has been found to be effective against a variety of bacteria causing wound infections. In vitro studies have revealed the efficacy of citric acid against bacteria resistant to multiple antibiotics. Clinical results with this treatment showed early formation of healthy granulation tissue and enhancement of the healing process (Nagoba et al., 1998, 1999, 2002).
In the present study, an attempt has been made to study the microbiological and histopathological response of chronic infected wounds following citric acid application (locally), and its correlation with clinical manifestations, in two cases. The citric acid was prepared in distilled water: 100 ml distilled water in a screw cap glass bottle was sterilized by autoclaving at 121 °C at 1.05 kg cm–2 pressure for 15 min to which 3 g citric acid was added taking all sterile precautions.