Abstract
Single-stranded polynucleotides (poly I and poly C), which do not generally have antiviral activity, became effective inducers of interferon when aggregated with different polycations. Poly I was consistently more active than poly C. The biological activity of the complexes depended more on the nature of the polycationic component than on the presence of the complementary base residue: introduction of covalently bound cytosine residue into the poly Ipolybase complex did not have any significant effect.