Abstract
Mice were inoculated in the left hind footpad with street rabies virus, and 24 h later various types of rabies vaccine were administered intramuscularly in the right leg. The vaccines alone were ineffective in reducing mortality, but when an interferon inducer, polyriboinosinic acid-polyribocytidylic acid complexed to poly-L-lysine (polyICLC), was given along with the vaccines, a marked reduction resulted. The polyICLC-vaccine combination was effective even when it was injected 5 days after infection, suggesting that effective postexposure treatment in man might be successful when given at a comparable late time.
* Present address: Sección de Rabia, Instituto Nacional de Investigaciones Veterinarias, Maracay, Venezuela.
† Present address: College of Veterinary Medicine, University of Georgia, Athens, Georgia, U.S.A.
‡ Present address: Laboratory of Viral Diseases, National Institutes of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Md. 20014, U.S.A.
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