Research Article

The effects of Clostridium difficile toxins A and B on membrane integrity and protein synthesis in intestinal cells in vivo and in vitro and in McCoy cells in vitro

Mitchell, T. J., Ketley, J. M., Burdon, D. W., Candy, D. C., Stephen, J.

Journal of Medical Microbiology 1987; 23(3):205

Abstract

Clostridium difficile toxins A and B inhibited protein synthesis in McCoy tissue-culture cells but not in intestinal cells in vitro or in vivo. Toxins A and B had no effect on membrane permeability of either intestinal cells or McCoy cells.