Genetic characteristics of one highly multi-drug-resistant strain of Klebsiella ozaenae

Jiansheng Huang, Xirong Li, Naishuo Zhu, Guoxiong Li

¹Lab of Molecular Immunology & State Key Lab of Genetic Engineering, Institute of Biomedical Sciences, School of Life Science, Fudan University, Shanghai 200433, PR China

²Department of Clinical Laboratory, Lishui Central Hospital, Zhejiang Province 323000, PR China

Correspondence
Naishuo Zhu nzhu{at}fudan.edu.cn

Journal of Medical Microbiology 2012; 61(Pt 9):1303–1305 · https://doi.org/10.1099/jmm.0.044115-0

Abstract

One highly multi-drug-resistant, mucus-producing and foul-smelling strain of Klebsiella ozaenae was isolated from a patient in the ICU of a Chinese tertiary hospital. MICs of several clinical antimicrobials against the strain were obtained using the Vitek-2 Compact System with AST-GN13 cards and resistance genes were evaluated by PCR and gene sequencing. The strain was resistant to most of the β-lactams and quinolones tested and carried several antibiotic resistance genes, including bla_KPC-2, bla_TEM-98, bla_CTX-M-3, bla_SHV-26 and qnrS. To our knowledge, this is the first report of β-lactam and quinolone resistance genes co-existing in a K. ozaenae strain in China.