Abstract
The sedimentation rate of human leukocyte interferon (HLIF) reactivated from sodium dodecyl sulphate (SDS) solution was studied by glycerol gradient centrifugation and compared to that of native HLIF. Reactivated HLIF consistently sedimented faster than native HLIF, indicating that full recovery of antiviral activity does not require renaturation of the entire interferon molecule.
* Present address: Frederick Cancer Research Center, NCI, Fort Detrick, Frederick, Maryland, USA.
† Present address: Laboratory of Viral Oncology, Institut de Recherches Scientifiques sur le Cancer, Villejuif, France.