Abstract
* Collège de France, Laboratoire de Médecine Expérimentale, 11 Place Marcelin Berthelot, 75231 Paris Cedex 05
† Institut National de la Santé et de la Recherche Médicale, Laboratoire de Biologie Cellulaire et de Culture de Tissus, 75005 Paris, France
An isolate (Mira) of cytomegalovirus is shown to replicate in human embryonic lung fibroblasts at supra-optimal temperature (40 °C). The ability of the Mira isolate to grow at 40 °C decreased as a function of age of cells in which the virus was grown. The unusual morphology of the lesions in late passage cells infected and maintained at 40 °C is illustrated.