Effect of trypsin treatment on the antigenic characteristics of plaque variants of type-O 1 and type Asia-1 foot-and-mouth disease viruses -- Cowan et al. 41 (2): 437 -- Journal of General Virology

Antigenic differences were demonstrated between the large and small plaque variants of both types O1 and Asia-1 foot-and-mouth disease viruses. Treatment of the large and small plaque variants of the viruses with trypsin essentially abolished the observed antigenic differences. Thus, these plaque variants have antigenically different trypsin-sensitive determinants that may influence their immunogenicity and infection capabilities.