SGM Journals
Research Article

Transformation and T Antigen Induction by Linearized BK Virus DNA

van der Noordaa, J., De Jong, W., Pauw, W., Sol, C. J. A., van Strien, A.

Journal of General Virology 1979; 44(3):843 · https://doi.org/10.1099/0022-1317-44-3-843

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Abstract

Linearized unit length DNA obtained after cleavage of the supercoiled DNA of the human papovavirus BKV by PstI (0.31) induced transformation and T antigen less efficiently than DNA cleaved by EcoRI (0.0), BamHI (0.98), KpnI (0.90) or HhaI (0.73). BKV DNA cleaved by XbaI (0.27 and 0.95) did not induce T antigen.