Research Article

Resistance to Interferon of a Human Adenocarcinoma Cell Line, HEC-1, and its Sensitivity to Natural Killer Cell Action

Journal of General Virology 1981; 52(1):177 · https://doi.org/10.1099/0022-1317-52-1-177

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Abstract

A human endometrial cancer cell line, HEC-1, was found to be resistant to the antiviral and anticellular action of interferon. However, HEC-1 cells were susceptible to the cytotoxicity of natural killer (NK) cells, and interferon enhanced such NK activity. When HEC-1 cells were treated with interferon, sensitivity of HEC cells to the cytotoxicity of NK cells was not suppressed.

Present address: National Institute of Preventive Medicine, Taipei, Taiwan.