Research Article

Interferon Stabilization and Enhancement by Rare Earth Salts

Journal of General Virology 1981; 52(1):195 · https://doi.org/10.1099/0022-1317-52-1-195

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Abstract

The addition of salts of the rare earth elements (lanthanides) enhances by a factor of two or more the initial activity of human fibroblast, leukocyte and immune interferons as well as mouse L-cell interferon. Furthermore, the salts of the lanthanides (0.01 to 0.002 M) preserve the activity of human fibroblast interferon not only after 4 days of heating at 37 °C but also after exposure to severe shearing forces; human leukocyte interferon was stabilized to a lesser degree, albeit significantly.