Abstract
1 Max-Planck-Institut für Biochemie, 8033 Martinsried bei München, Federal Republic of Germany
2 Institut de Virologie, Tours, France
3 MHH, Dept. für Innere Medizin, 3000 Hannover 61, Federal Republic of Germany
Hepatitis B virus-related DNA was detected in the chromosomal DNA of three out of seven hepatocellular carcinomas and two out of five cirrhosis samples examined, by means of the blot-hybridization technique, described by Southern (1975). The integration patterns were not identical but some similarities raise the question of whether there are some preferred sites of viral integration.