Research Article

Unusually long target site duplications flanking some of the long terminal repeats of human endogenous retrovirus K in the human genome

Journal of General Virology 2004; 85(6):1485 · https://doi.org/10.1099/vir.0.19717-0

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Abstract

Human endogenous retroviruses (HERVs) make up a substantial part of the human genome. HERVs and solitary long terminal repeats (solo LTRs) are usually flanked by 46 nt short direct repeats through the well-known mechanism of their integration. A number of solo LTRs flanked by unusually long direct repeats were detected in the human genome. These unusual structures might be a product of an alternative virus insertion mechanism.

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